China (Mainland)
High purity Monomethyl auristatin E 474645-27-7 with best price CAS NO.474645-27-7
- FOB Price: USD: 20.00-30.00 /Kilogram Get Latest Price
- Min.Order: 25 Kilogram
- Payment Terms: T/T,MoneyGram
- Available Specifications:
99%(1-10)Kilogram99%(10-100)Kilogram99.9%(101-1000)Kilogram
- Product Details
Keywords
- Monomethyl auristatin E
- 474645-27-7
- MMAE
Quick Details
- ProName: High purity Monomethyl auristatin E 47...
- CasNo: 474645-27-7
- Molecular Formula: C39H67N5O7
- Appearance: White Powder
- Application: API
- DeliveryTime: 3-10 working days
- PackAge: AS YOUR REQUIREMENT
- Port: Tianjin/Shenzhen
- ProductionCapacity: 50 Kilogram/Day
- Purity: 99%
- Storage: Keep it in dry, cool and ventilated pl...
- Transportation: by air or sea
- LimitNum: 25 Kilogram
- Moisture Content: 0.1%
- Impurity: 0.1%
- China Hebei: shijiazhuang Wego
- Proname: Monomethyl auristatin E
- 474645-27-7: C39H67N5O7
Superiority
WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE
1)Quick Response Within 12 hours;
2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France etc.
3) OEM/ODM Available;
4) Reasonable & Competitive Price;
5) Fast Delivery: Samples from stock; bulk products within 7 days;
6) Professional Documents for Your Clearance;
7) Economic Freight Save Your Cost;
8) All your money be refund immediately if quality issue happens.
IN STOCK HIGH QUALITY BEST PRICE
We could give you:
1.Best quality in your requirement
2.Competitive price in china market
3.Mature technical support
4.Professional logistic support all we want is win-win business. send yr. inquiries, you will get it!
Details
| MonoMethyl auristatin E Basic information |
| Product Name: | MonoMethyl auristatin E |
| Synonyms: | MonoMethyl auristatin E(MMAE, vedotin);HM-297C-22;MonoMethyl auristatin E;MMAE;Vedotin;N-Methyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide Monomethyl;Monomethyl auristatin E, >=98%;(S)-N-((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((1R,2R)-1-Hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidin-1-yl)-3-methoxy-5-methyl-1-oxohe |
| CAS: | 474645-27-7 |
| MF: | C39H67N5O7 |
| MW: | 717.98 |
| MonoMethyl auristatin E Chemical Properties |
| Boiling point | 873.5±65.0 °C(Predicted) |
| density | 1.088±0.06 g/cm3(Predicted) |
| pka | 13.66±0.20(Predicted) |
| MonoMethyl auristatin E Usage And Synthesis |
| Chemical Properties | Monomethyl auristatin E (MMAE) is a synthetic antineoplastic agent. Because of its toxicity, it cannot be used as a drug itself; instead, it is linked to a monoclonal antibody (MAB) which directs it to the cancer cells. In International Nonproprietary Names for MMAE-MAB-conjugates, the name vedotin refers to MMAE plus its linking structure to the antibody. It is a potent antimitotic drug derived from peptides occurring in marine shell-less mollusc Dolabella auricularia called dolastatins which show potent activity in preclinical studies, both in vitro and in vivo, against a range of lymphomas, leukemia and solid tumors. These drugs show potency of up to 200 times that of vinblastine, another antimitotic drug used for Hodgkin lymphoma as well as other types of cancer. MMAE is actually desmethyl-auristatin E; that is, the N-terminal amino group has only one methyl substituent instead of two as in auristatin E itself. |
| Uses | Dolastatin 10 is a natural antimitotic and antineoplastic agent that binds to tubulin and inhibits tubulin polymerization. Monomethyl Auristatin E (MMAE) is a synthetic analog of dolastatin 10 that similarly inhibits tubulin polymerization and exhibits potent cytotoxicity. It is commonly conjugated with monoclonal antibodies directed at antigens specific to cancer cells for tumor-directed cytotoxicity. MMAE is typically coupled to the antibody via a protease-cleavable linker, allowing separation of the drug from the antibody following intracellular localization.[Cayman Chemical] |
Why Choose Us
1.Selecting raw materials strictly,our products are the highest purity.
2.Reasonable and competitive price. Provide the best and professional service.
3.Fast delivery of the samples ,samples from stock. Reliable shipping way.
4.Full experience of large numbers containers loading in Chinese sea port.
5.Best after-service after shipment .
6.Professional documents for your custom clearance.
FAQ
Q: How to start orders or make payments
A: You can send our your Purchase order by email or by Trade Manager, and we will send you Proforma Invoice with our bank details for your confirmation, then you can make payment accordingly.
Q: How to confirm the Product Quality before placing orders
A: You can get free samples for some products, you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests, we will manufacture the products according to your requests.
Q: What's your MOQ
A: For the high value product, our MOQ starts from 1g and generally starts from 1kgs. For other low value product, our MOQ starts from 10kg and 100kg.
Q: Is there a discount
A: Different quantity has different discount, for larger quantity, we alway support with better price.
Q: How to contact us
A: You can chat with us by Trade manager, Whatsapp & Skype Online. You can choose your interested products and send inquiry to us. You can dial our telephone directly, you will get our reply. Send Email to us.
Company information:
Hebei wego import and export Co. LTD is located in Hebei province of China, limited is specialized in the production of high complex new type intermediates and chemical custom synthesis, scale-up production and rare chemicals trade. products category is including intermediates & api, catalyst, electronic chemicals and other research chemicals.
we are adhering to the consistent good commercial reputation, to create a highly efficient, high quality of chemical research, development, production, sales and service of integrated platform, to make our customers easy to order.
all of our company is committed to provide high quality chemicals, competitive price, best service, fast shipping and stable supply to our loyal customers.